wxGlade is an open source graphical user interface builder written in Python using popular widget toolkit wxWidgets.
wxGlade allows to create graphical user interfaces using wxWidgets. The designer can arrange different widgets using a drag and drop WYSIWYG editor. This simplifies the creation of a graphical user interface in comparison with manual coded graphical user interfaces.
wxGlade is able to generate source code for Python, Perl, Lisp, C++ and XRC based on the designed GUI.
As you can guess by the name, its model is Glade, the famous GTK+/GNOME GUI builder, with which wxGlade shares the philosophy and the look & feel (but not a line of code).